ABSTRACT
The new type of coronavirus pneumonia (new coronary pneumonia for short), due to its strong infectivity and rapid spread, poses a major threat to public health and greatly increases the burden on society. Since there is no specific medicine for new coronary pneumonia, prevention and stopping the spread of the epidemic are the focus of epidemic prevention work. The new crown pneumonia belongs to the category of "epidemic" and "plague" in Chinese medicine. Epidemics have been pandemic in ancient China. Either "Huangdi Neijing", "Treatise on Febrile Diseases", or in the works of the Febrile Disease School in the Ming and Qing Dynasties, we can see the discussion of "disease". For thousands of years, Chinese medicine has accumulated accumulated efforts in preventing the spread and prevalence of the epidemic in the process of constantly fighting against the epidemic.
ABSTRACT
BACKGROUD: The association between underlying comorbidities and cardiac injury and the prognosis in coronavirus disease 2019 (COVID-19) patients was assessed in this study. HYPOTHESIS: The underlying comorbidities and cardiac injury may be associated with the prognosis in COVID-19 patients. METHODS: A systematic search was conducted in PubMed, EMBASE, Web of science, and The Cochrane library from December 2019 to July 2020. The odds ratio (OR) and 95% confidence intervals (95% CI) were used to estimate the probability of comorbidities and cardiac injury in COVID-19 patients with or without severe type, or in survivors vs nonsurvivors of COVID-19 patients. RESULTS: A total of 124 studies were included in this analysis. A higher risk for severity was observed in COVID-19 patients with comorbidities. The pooled result in patients with hypertension (OR 2.57, 95% CI: 2.12-3.11), diabetes (OR 2.54, 95% CI: 1.89-3.41), cardiovascular diseases (OR 3.86, 95% CI: 2.70-5.52), chronic obstractive pulmonary disease (OR 2.71, 95% CI: 1.98-3.70), chronic kidney disease (OR 2.20, 95% CI: 1.27-3.80), and cancer (OR 2.42, 95% CI: 1.81-3.22) respectively. All the comorbidities presented a higher risk of mortality. Moreover, the prevalence of acute cardiac injury is higher in severe group than in nonsevere group, and acute cardiac injury is associated with an increased risk for in-hospital mortality. CONCLUSION: Comorbidities and acute cardiac injury are closely associated with poor prognosis in COVID-19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID-19 patients.